
Sequence Optimization
Great Bay Bio’s Antibody Discovery & Sequence Optimization Service integrates functional screening with AI-driven AlfaBodY & AlfaDAX platform to deliver lead candidates characterized by both high biological potency and superior manufacturability. By addressing immunogenicity and stability at the sequence level, we reduce the probability of clinical failure and accelerate the transition from discovery to IND.
AlfaDAX Antibody Optimization: End-to-end optimization completed in ~2 months, enabling rapid progression to PCC.
Simultaneous optimization of affinity, humanization, and developability to generate clinical-grade antibodies with high activity, reduced risk, and strong manufacturability.
20+ projects | 83% success rate
Platform Advantages
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Structure simulation and assessment |
using in-house AI algorithm |
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Humanization, affinity and developability |
be optimized simultaneously |
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Based on >1000 antibodies |
reliable cut-off value verification |
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PCC to stable cell line |
Ensure the antibody development |