Sequence Optimization

Great Bay Bio’s Antibody Discovery & Sequence Optimization Service integrates functional screening with AI-driven AlfaBodY & AlfaDAX platform to deliver lead candidates characterized by both high biological potency and superior manufacturability. By addressing immunogenicity and stability at the sequence level, we reduce the probability of clinical failure and accelerate the transition from discovery to IND.


AlfaDAX Antibody Optimization: End-to-end optimization completed in ~2 months, enabling rapid progression to PCC.


Simultaneous optimization of affinity, humanization, and developability to generate clinical-grade antibodies with high activity, reduced risk, and strong manufacturability.


20+ projects | 83% success rate

Platform Advantages

Structure simulation and assessment
using in-house AI algorithm
Humanization, affinity and developability
be optimized simultaneously
Based on >1000 antibodies
reliable cut-off value verification
PCC to stable cell line
Ensure the antibody development

Case Study

Global Bioprocessing Made Simpler and More Efficient