Antibody Design
Fast: 8 months, From Target to PCC Enabled for Difficult Targets Low CMC Risk
Introduction
AlfaBodY is a structure-based AI algorithm that designs novel antibody sequences — covering both framework regions and CDRs — from a given variable region. By integrating developability predictions from the AlfaDAX platform throughout the workflow, it typically requires only 3-5 rounds of dry–wet lab cycles to generate antibodies that are structurally distinct from the template and exhibit superior properties, including higher affinity, improved developability, and enhanced efficacy.
Advantages
8 months
In vitro and In vivo validation
3 weeks per cycle
AI sequence design + expression validation
Combined dry and wet lab work
AI sequence design + activity tested
Sequence design integrated with developability
AI prediction + experimental validation
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